■2024年■
126. K. Nishiwaki, S. Nakatani, S. Nakamura, K. Yoshioka, E. Nakagawa, M. Tsuyuguchi, T. Kinoshita, I. Nakanishi, Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water, RSC Med. Chem., in press.
125. S. Hasegawa, M. Yoshida, H. Nagao, H. Sugiyama, M. Sawa, T. Kinoshita,
Distinct binding modes of a benzothiazole derivative confer structural
bases for increasing ERK2 or p38α MAPK selectivity, Biochem. Biophys. Res. Commun.704, 149707 (2024)
■2023年■
124. K. Nishiwaki, S. Nakamura, K. Yoshioka, E. Nakagwa, S. Nakatani, M.
Tsuyuguchi, T. Kinoshita, I. Nakanishi, Design, synthesis and structure-activity
relationship studies of protein kinase CK2 inhibitors containing a purine
scafold, Chem. Phram. Bull. 71, 558-565 (2023).
123. H. Sugiyama, M. Yoshida, H. Nagao, M. Sawa, T. Kinoshita, Low entropic
cost of binding confers high selectivity on an allosteric ERK2 inhibitor,
Bioorg. Med. Chem. Lett. 93, 129431 (2023).
■2022年■
122. A. Ikeda, M. Tsuyuguchi, D. Kitagawa, M. Sawa, S. Nakamura, I. Nakanishi,
T. Kinoshita, Bivalent binding mode of an amino-pyrazole inhibitor indicates
the potentials for CK2a1-selective inhibitors, Biochem. Biophys. Res. Commun.630, 30-35 (2022).
121. M. Yoshida, H. Nagano, H. Sugiyama, M. Sawa, T. Kinoshita, Identification
of a novel target site for ATP-independent ERK2 inhibitors, Biochem. Biophys. Res. Commun. 593, 73-78 (2022).
■2021年■
120. H. Nagao, D. Kitagawa, F. Nakajima, M. Sawa, T. Kinoshita, Identification
of an allosteric and Smad3-selective inhibitor of p38aMAPK using a substrate-based
approach, Bioorg. Med. Chem. Lett. 31, 128056 (2021).
■2020年■
119. Y. Murakawa, S. Valter, H. Barr, N. London, T. Kinoshita, Structural
basis for producing selective MAP2K7 inhibitors, Bioorg. Med.Chem. Lett.30, 127546 (2020).
118. M. Tsuyuguchi, T. Nakaniwa, A. Hirasawa, I. Nakanishi, T. Kinoshita,
Structural insights for producing CK2a1-specific inhibitors, Bioorg. Med. Chem. Lett. 30, 126837 (2020).
117. N. Furuya, T. Momose, K. Katsuno, N. Fushimi, H. Muranaka, C. Handa,
M. Sawa, T. Ozawa, T. Kinoshita, An isoform-selective inhibitor of tropomyosin
receptor kinase A behaves as molecular glue, Bioorg. Med. Chem. Lett.30, 126775 (2020).
116. T. Matsumoto, A. Yamano, Y. Murakawa, H. Fukada, M. Sawa, T. Kinoshita,
Ensemble structural analyses depict the regulatory mechanism of non-phosphrylated
human MAP2K4, Biochem. Biophys. Res. Commun.521, 106-112 (2020).
■2019年■
115. M. Tsuyuguchi, T. Nakaniwa, M. Sawa, I. Nakanishi, T. Kinoshita, A
promiscuous kinase inhibitor delineates the conpicuous structural features
of protein kinase CK2a1, Acta Cryst. F75, 515-519 (2019).
114. T. Oshima, Y. Niwa, K. Kuwata, A. Srivastava, T. Hyoda, T. Tsuchiya,
M. Kumagai, M. Tsuyuguchi, T. Tamaru, A. Sugiyama, N. Ono, N. Zolboot,
Y. Aikawa, S. Oishi, A. Nonami, F. Arai, M. Ikeda, T. Kinoshita, S.A. Kay,
K. Itami, T.Hirota, Cell-based screen identifies a new potent and highly
selective CK2 ihibiotor for modulation of circadian rhythms and cancer
cell growth, Sci. Adv.5, eaau9060 (2019).
113. A. Sharaga, E. Olhavang, N. Davidzohn, P. Khoshkenar, N. Germain,
K. Shurrush, S. Carvalho, L. Avram, S. Albeck, T. Unger, B. Lefker, C.
Subramanyam, R.H. Hudkins, A. Mitchell, Z. Shulman, T. Kinoshita, N. London,
Covalent docking identifies a potent and selective MKK7 inhibitor, Cell Chem. Biol. 26, 98-108 (2019).
112. T. Kinoshita, T. Hashimoto, Y. Murakawa, Y. Sogabe, T. Matsumoto,
M. Sawa, A microgravity environment improves structural resolution and
endows cues for specific inhibition of mitogen-activated protein kinase
kinase 7, Int. J. Microgravity Sci. Appl.36, 380102 (2019).
■2018年■
111. C. Shibasaki, S. Arai, R. Shimizu, M. Saeki, T. Kinoshita, A. Ostermann,
T.T. Schrader, Y. Kurosaki, T. Sunami, R. Kuroki, M. Adachi, Hydration
structures of the human protein kinase CK2a clarified by joint neutron
and X-ray crystallography, J, Mol. Biol.430, 5094-5104 (2018).
110. M. Tsuyuguchi, T. Nakaniwa, T. Kinoshita, Crystal structures of human
CK2a2 in new crystal forms arising from a subtle difference in salt concentration,
Acta Crystallogr. F74, 288-293 (2018).
109. A. Nishiyama, T. Yamada, K. Kita, R. Wang, S. Arai, K. Fukuda, A.
Tanimoto, S. Takeuchi, S. Tange, A. Tajima, N. Furuya, T. Kinoshita, S.
Yano, Foretinib overcomes entrectinib resistanse associated with the NTRK1
G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastatis
model, Clinical Cancer Res. 24, 2357-2369 (2018).
■2017年■
108. T. Kinoshita, T. Hashimoto, Y. Sogabe, H. Fukada, T. Matsumoto, M.
Sawa, High-resolution structure discloses the potential for the allosteric
regulation of mitogen-activated protein kinase kinase 7, Biochem. Biophys.Res. Commun.493, 313-317(2017).
107. N. Furuya, T. Momose, K. Katsuno, N. Fushimi, H. Muranaka, C. Handa,
T. Ozawa, T. Kinoshita, The juxtamembrane region of TrkA kinase is critical
for inhibitor selectivity, Bioorg. Med. Chem. Lett. 27, 1233-1236 (2017).
■2016年■
106. Y. Sogabe, T. Hashimoto, T. Matsumoto, Y. Kirii, M. Sawa, T. Kinoshita,
A crucial role of Cys218 in configuring an unprecedented auto-inhibition
form of MAP2K7, Biochem. Biophys. Res. Commun. 473, 476-481 (2016).
105. H. Ohno, D. Minamiguchi, S. Nakamura, K. Shu, S. Okazaki, M. Honda,
R. Misu, H. Moriwaki, S. Nakanishi, S. Oishi, T. Kinoshita, I. Nakanishi,
N. Fujii, Structure-activity relationship study of 4-(thiazol-5-yl)benzoic
acid derivatives as potent protein kinase CK2 inhibitors, Bioorg. Med. Chem.24, 1136-1141 (2016).
104. T. Kinoshita, H. Sugiyama, Y. Mori, N. Naruhide, A. Tomonaga, Identification
of allosteric ERK2 inhibitors in silico biased screening and competitive
binding assay, Boorg. Med. Chem. Lett. 26, 955-958 (2016).
■2015年■
103. S. Sasamura, M. Kobayashi, H. Muramatsu, S. Yoshimura, T. Kinoshita,
H. Ohki, K. Okada, Y. Deai, Y. Yamagishi, M. Hashimoto, Bioconversion of
FR901459, a novel derivative of cyclosporin A, by Lentzea sp. 7887, J. Antibiotics68, 511-520 (2015).
102. I. Nakanishi, K. Murata, N. Nagata, M. Kurono, T. Kinoshita, M. Yasue,
T. Miyazaki, Y. Takei, S. Nakamura, A. Sakurai, N. Iwamoto, K. Nishiwaki,
T. Nakaniwa, Y. Sekiguchi, A. Hirasawa, G. Tsujimoto, K. Kitaura, Identification
of protein kinase CK2 inhibitors using solvent dipole ordering virtual
screening, Eur. J. Med. Chem.96, 396-404 (2015).
101. Y. Sogabe, T. Matsumoto, T. Hashimoto, Y. Kirii, M. Sawa, T. Kinoshita,
5Z-7-oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented
manner, Boorg. Med. Chem. Lett. 25, 593-596 (2015).
■2014年■
100. K. Sakai, T. Kinoshita, K. Matsumoto, Hepatocyte growth factor, Reference Module in Biomedical Science 2014, 1-10 (2014).
■2013年■
99. T. Kinoshita, T. Nakaniwa, Y. Sekiguchi, Y. Sogabe, A. Sakurai, S. Nakamura, I. Nakanishi, Crystal structure of human CK2a at 1.06 Å resolution, J. Synchrotron Rad. 20, 974-979 (2013).
■2012年■
98. T. Nakaniwa, H. Fukada, T. Inoue, M. Gouda, R. Nakai, Y. Kirii, M.
Adachi, T. Tamada, S. Segawa, R. Kuroki, T. Tada, T. Kinoshita*, Seven
cysteine-deficient mutants depict interplay between thermal and chemical
stabilities of individual cysteine residues in MAP kinase JNK1, Biochemistry51, 8410-8421 (2012).
97. T. Matsumoto, T. Kinoshita, Y. Kirii, T. Tada, A. Yamano, Crystal and
solution structures disclose a putative transient state of mitogen-activated
kinase kinase 4, Biochem. Biophys. Res. Commun. 425, 195-200 (2012).
96. Z. Hou, I. Nakanishi, T. Kinoshita, Y. Takei, M. Yasu, Y. Suzuki, S.
Nakamura, T. Kure, H. Ohno, K. Murata, K. Kitaura, A. Hirasawa, G. Tsujimoto,
S. Oishi, N. Fujii, Structure-based design of novel potent protein kinase
CK2 (CK2) inhibitors with phenyl-azole scaffolds, J. Med. Chem.55, 2899-2903 (2012).
95. T. Matsumoto, T. Kinoshita, H. Furukawa, R. Nakai, Y. Kirii, K. Yokota,
T. Tada, Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition
state, J. Biochem. 151, 541-549 (2012).
94. Y. Takashima, E. Mizohata, S.R. Krungkrai, Y. Fukunishi, T. Kinoshita,
T. Sakata, H. Matsumura, J. Krungkrai, T. Horii, T. Inoue, The in silico
screening and X-ray analysis of the inhibitor complex of Plasmodium falciparum
orotidine-5’-monophosphate decarboxylase, J. Biochem. 152, 133-138 (2012).
■2011年■
93. T. Kinoshita, Y. Sekiguchi, H. Fukada, T. Nakaniwa, T. Tada, S. Nakamura,
K. Kitaura, H. Ohno, Y. Suzuki, A. Hirasawa, I. Nakanishi, G. Tsujimoto,
A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives
binding to CK2 kinase, Mol. Cell. Biochem. 356, 97-105 (2011).
92. T. Kinoshita, K. Doi, H. Sugiyama, S. Kinoshita, M. Wada, S. Naruto,
A. Tomonaga, Knowledge-based identification of the ERK2/STAT3 signal pathway
as a therapeutic target of type 2 diabetes and drug discovery, Chem. Biol. Drug Des. 78, 471-476 (2011).
91. K. Sakai, T. Nakamura, T. Kinoshita, T. Nakamura, K. Matsumoto, HGF-antagonists:
structure, activities, and anti-cancer approach, Current Signal Transduction Therapy6, 191-199 (2011).
90. Y. Sogabe, T. Kitatani, A. Yamaguchi, T. Kinoshita, H. Adachi, K. Takano,
T. Inoue, Y. Mori, H. Matsumura, T. Sakamoto, T. Tada, High-resolution
structure of exo-arabinanase from Penicillium Chrysogenum, Acta Crystallogr.D67, 415-422 (2011).
■2010年以前■
89. T. Matsumoto, T. Kinoshita, Y. Kirii, K. Yokota, K. Hamada, T. Tada,
Crystal structures of MKK4 kinase domain reveal that substrate peptide
binds to an allosteric site and induces an auto-inhibition state, Biochem. Biophys. Res. Commun. 400, 369-373 (2010).
88. X. Yang, T. Kinoshita, M. Gouda, K. Yokota, T. Tada, A silent mutation
allows efficient production of active human Frk tyrosine kinase in Escherichia
coli, Biosci. Biotechnol. Biochem. 74, 125-128 (2010).
87. N. Miyano, T. Kinoshita, R. Nakai, Y. Kirii, K. Yokota, T. Tada, Structure
Basis for the inhibitor recognition of human Lyn kinase domain, Bioorg. Med. Chem. Lett. 19, 6557-6560 (2009).
86. T. Tamada, T. Kinoshita, K. Kurihara, M. Adachi, T. Ohhara, K. Imai,
R. Kuroki, T. Tada, Combined high-resolution neutron and x-ray analysis
of inhibited elastase confirms the active-site oxyanion hole but rules
against a low-barrier hydrogen bond, J. Am. Chem. Soc. 131, 11033-11040 (2009).
85. Y. Sekiguchi, T. Nakaniwa, T. Kinoshita, I. Nakanishi, K. Kitaura,
A. Hirasawa, G. Tsujimoto, T. Tada, Structural insight into human CK2a
in complex with the potent inhibitor ellagic acid, Bioorg. Med. Chem. Lett. 19, 2920-2923 (2009).
84. T. Nakaniwa, T. Kinoshita, Y. Sekiguchi, T. Tada, I. Nakanishi, K.
Kitaura, Y. Suzuki, H. Ohno, A. Hirasawa, G. Tsujimoto, Structure of human
protein kinase CK2a2 with a potent indazole-derivative inhibitor, Acta Crystallogr. F65, 75-79 (2009).
83. T. Kinoshita, I. Yoshida, S. Nakae, K. Okita, M. Gouda, M. Matsubara,
K. Yokota, H. Ishiguro, T. Tada, Crystal structure of human mono-phosphorylated
ERK1 at Tyr204, Biochem. Biopys. Res. Commun. 377, 1123-1127 (2008).
82. T. Kinoshita, T. Tada, I. Nakanishi, Conformational change of adenosine
deaminase during ligand-exchange in a crystal, Biochem. Biopys. Res. Commun. 373, 53-57 (2008).
81. T. Kinoshita, N. Miyano, R. Nakai, K. Yokota, H. Ishiguro, T. Tada,
Protein purification and preliminary crystallographic analysis of human
Lyn tyrosine kinase, Protein Expr. Purif. 58, 318-324 (2008).
80. T. Kinoshita, T. Tamada, K. Imai, K. Kurihara, T. Ohhara, T. Tada,
R. Kuroki, Crystallization of porcine pancreatic elastase and preliminary
neutron diffraction experiment, Acta Cryst. F63, 315-317 (2007).
79. M. Ohori, T. Kinoshita, S. Yoshimura, M. Warizaya, H. Nakajima, H.
Miyake, Role of a cysteine residue in the active site of ERK and the MAPKK
family, Biochem. Biophys. Res. Commun. 353, 633-637 (2007).
78. T. Kitatani, Y. Nakamura, K. Wada, T. Kinoshita, M. Tamoi, S. Shigeoka,
T. Tada, Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from
Synechococcus PCC7942, Acta Cryst. F62, 727-730 (2006).
77. T. Kinoshita, A. Yamaguchi, T. Tada, Tris(hydroxymethyl)aminomethane
induces conformational change and crystal-packing contraction of porcine
pancreatic elastase, Acta Cryst. F62, 623-626 (2006).
76. T. Kinoshita, M. Matsubara, H. Ishiguro, K. Okita, T. Tada, Structure
of human Fyn kinase domain complexed with staurosporine, Biochem. Biophys. Res. Commun. 346, 840-844 (2006).
75. T. Kitatani, Y. Nakamura, K. Wada, T. Kinoshita, S. Shigeoka, T. Tada,
Structure of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from
Synechococcus PCC7942 complexed with NADP, Acta Cryst. F62, 315-319 (2006).
74. M. Kuno, N. Seki, S. Tsujimoto, I. Nakanishi, T. Kinoshita, K. Nakamura,
T. Terasaka, N. Nishio, A. Sato, T. Fujii, Anti-inflammatory activity of
non-nucleoside adenosine deaminase inhibitor FR234938, Eur. J. Pharmacol. 534, 241-249 (2006).
73. H. Adachi, A. Niino, T. Kinoshita, M. Warizaya, R. Maruki, K. Takano,
H. Matsumura, T. Inoue, S. Murakami, Y. Mori, T. Sasaki, Solution-stirring
method improves crystal quality of human triosephosphate isomerase, J. Biosci. Bioeng. 101, 83-86 (2006).
72. J. Ishida, H. Yamamoto, Y. Kido, K. Kamijo, K. Murano, H. Miyake, M.
Okubo, T. Kinoshita, M. Warizaya, A. Iwashita, K. Mihara, N. Matsuoka,
K. Hattori, Discovery of potent and selective PARP-1 and PARP-2 inhibitors:
SBDD analysis via a combination of X-ray structural study and homology
modeling, Bioorg. Med. Chem.14, 1378-1390 (2006).
71. T. Kinoshita, M. Warizaya, M. Ohori, K. Sato, M. Neya, T. Fujii, Crystal
structure of human ERK2 complexed with a pyrazolo[3,4c]pyridazine derivative,
Bioorg. Med. Chem. Lett. 16, 55-58 (2006).
70. A. Iwashita, K. Hattori, H. Yamamoto, J. Ishida, Y. Kido, K. Kamijo,
K. Murano, H. Miyake, T. Kinoshita, M. Warizaya, M. Ohkubo, N. Matsuoka,
S. Mutoh, Discovery of quinazolinone and quinoxaline derivatives as potent
and selective poly(ADP-ribose) polymerase-1/2 inhibitors, FEBS Lett. 579, 1389-1393, (2005).
69. H. Adachi, A. Niino, S. Murakami, K. Takano, H. Matsumura, T. Kinoshita,
M. Warizaya, T. Inoue, Y. Mori and T. Sasaki, Protein crystallization by
combining laser irradiation and solution-stirring techniques, Jpn. J. Appl. Phys. 44, 1365-1366, (2005).
68. T. Kinoshita, R. Maruki, M. Warizaya, H. Nakajima and S. Nishimura,
Structure of a high-resolution crystal form of human triosephosphate isomerase:
improvement of crystals using the gel-tube method, Acta Cryst. F61, 346-349, (2005).
67. H. Adachi, K. Takano, A. Niino, H. Matsumura, T. Kinoshita, M. Warizaya,
Y. Mori, T. Sasaki, Solution stirring initiates nucleation and improves
the quality of adenosine deaminase crystals, Acta Cryst. D61, 759-762, (2005).
66. T. Terasaka, K. Tsuji, T. Kato, I. Nakanishi, T. Kinoshita, Y. Kato,
M. Kuno, T. Inoue, K. Tanaka and K. Nakamura, Rational design of non-nucleoside,
potent, and orally bioavailable adenosine deaminase inhibitors: predicting
enzyme conformational change and metabolism, J. Med. Chem. 48, 4750-4753, (2005).
65. T. Kinoshita, I. Nakanishi, T. Terasaka, M. Kuno, N. Seki, M. Warizaya,
H. Matsumura, T. Inoue, K. Takano, H. Adachi, Y. Mori, T. Fujii, Structural
basis of compound recognition by adenosine deaminase, Biochemistry. 44, 10562-10569, (2005).
64. T. Kinoshita, T. Kitatani, M. Warizaya, T. Tada, Structure of the complex
of porcine pancreatic elastase with a trimacrocyclic peptide inhibitor
FR901451, Acta Cryst. F61, 808-811, (2005).
63. M. Ohori, T. Kinoshita, M. Okubo, K. Sato, A. Yamazaki, H. Arakawa,
S. Nishimura, N. Inamura, H. Nakajima, M. Neya, T. Fujii, Identification
of a selective ERK inhibitor and structural determination of the inhibitor-ERK2
complex, Biochem. Biophys. Res. Commun. 336, 357-363, (2005).
62. M. Kobayashi, S. Yoshimura, T. Kinoshita, M. Hashimoto, S. Hashimoto,
S. Takase, A. Fujie, M. Hino, Y. Hori, FR207944, an Antifungal Antibiotic
from Chaetomium sp. No.217. II. Isolation and Structure Elucidation, Biosci. Biotechnol. Biochem. 69, 1029-1032 (2005).
61. Y. Ohtsu, S. Yoshimura, T. Kinoshita, S. Takase, H. Nakajima, The novel
gluconeogenesis inhibitor FR225654 that originates from Phoma sp. No. 00144
II. Structure determination, J. Antibiot. 58, 479-482 (2005).
60. B. Sato, H. Nakajima, T. Fujita, S. Takase, S. Yoshimura, T. Kinoshita,
H. Terano, FR177391, a new anti-hyperlipidemic agent from Serratia, J. Antibiot. 58, 634-639 (2005).
59. A. Otaka, J. Watanabe, A. Yukimasa, Y. Sasaki, H. Watanabe, T. Kinoshita,
S. Oishi, H. Tamamura, N. Fujii, SmI2-mediated reduction of ,-difluoro-,-enoates
with application to the synthesis of functionalized (Z)-fluoroalkene-type
dipetide isosteres, J. Org. Chem. 69, 1634-1645 (2004).
58. T. Kinoshita, T. Tsutsumi, R. Maruki, M. Warizaya, Y. Ishii, T. Fujii,
Cloning, expression, purification, crystallization and preliminary diffraction
analysis of the C-terminal catalytic domain of human poly(ADP-ribose) polymerase,
Acta Cryst. D60, 109-111 (2004).
57. T. Terasaka, T. Kinoshita, M. Kuno, I. Nakanishi, A highly potent non-nucleotide
adenosine deaminase inhibitor: efficient drug discovery by intentional
lead hybridization, J. Am. Chem. Soc. 126, 34-35 (2004).
56. T. Kinoshita, I. Nakanishi, M. Warizaya, A. Iwashita, Y. Kido, K. Hattori,
T. Fujii, Inhibitor-induced structural change of the active site of human
poly(ADP-ribose) polymerase, FEBS Lett. 556, 43-46 (2004).
55. M. Warizaya, T. Kinoshita, A. Kato, H. Nakajima, T. Fujii, Cloning,
expression, purification, crystallization and preliminary diffraction analysis
of human liver glyceraldehyde-3-phophate dehydrogenase, Acta Cryst. D60, 567-568 (2004).
54. H. Adachi, H. Matsumura, A. Niino, K. Takano, T. Kinoshita, M. Warizaya,
T. Inoue, Y. Mori, T. Sasaki, Improving the quality of protein crystals
using stirring crystallization, Jpn. J. Appl. Phys. 43, L522-L525 (2004).
53. T. Terasaka, H. Okumura, K. Tsuji, T. Kato, I. Nakanishi, T. Kinoshita,
Y. Kato, M. Kuno, N. Seki, Y. Naoe, T. Inoue, K. Tanaka, K. Nakamura, Structure-based
design and synthesis of non-nucleoside, potent, and orally bioavailable
adenosine deaminase inhibitors, J. Med. Chem. 47, 2728-2731 (2004).
52. H. Adachi, H. Matsumura, A. Niino, K. Takano, T. Kinoshita, M. Warizaya,
T. Inoue, Y. Mori, T. Sasaki, Generation of protein crystals using a solution-stirring
technique, Jpn. J. Appl. Phys. 43, L762-L764 (2004).
51. T. Terasaka, T. Kinoshita, M. Kuno, N. Seki, K. Tanaka, I. Nakanishi,
Structure-based design, synthesis, and structure-activity relationship
studies of novel non-nucleoside adenosine deaminase inhibitors, J. Med. Chem. 47, 3730-3743 (2004).
50. K. Hattori, Y. Kido, H. Yamamoto, J. Ishida, K. Kamijo, K. Murano,
M. Ohkubo, T. Kinoshita, A. Iwashita, K. Mihara, S. Yamazaki, N. Matsuoka,
Y. Teramura, H. Miyake, Rational approaches to discovery of orally active
and brain penetrable PARP inhibitors, J. Med. Chem. 47, 4151-4154, (2004).
49. M. Warizaya, T. Kinoshita, M. Yamaoka, T. Shibata, N. Saito, H. Nakajima
and T. Fujii, Expression, purification, crystallization and preliminary
X-ray diffraction studies of human liver regucalcin, Acta Cryst. D60, 2019-2021, (2004).
48. A. Niino, H. Adachi, K. Takano, H. Matsumura, T. Kinoshita, M. Warizaya,
T. Inoue, Y. Mori and T. Sasaki, Control of protein crystal nucleation
and growth using stirring solution, Jpn. J. Appl. Phys. 43, L1442-L1444, (2004).
47. T. Kinoshita, I. Nakanishi, A. Sato, T. Tada, True interaction mode
of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor,
Bioorg. Med. Chem. Lett. 13, 21-24 (2003).
46. T. Kinoshita, N. Nishio, I. Nakanishi, A. Sato, T. Fujii, Structure
of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine
riboside, Acta Cryst. D59, 299-303 (2003).
45. T. Terasaka, I. Nakanishi, K. Nakamura, Y. Eikyu, T. Kinoshita, N.
Nishio, A. Sato, M. Kuno, N. Seki, K. Sakane, Structure-based de novo design
of non-nucleoside adenosine deaminase inhibitors, Bioorg. Med. Chem. Lett. 13, 1115-1118 (2003).
44. T. Kinoshita, M. Ataka, M. Warizaya, M. Neya, T. Fujii, Improving quality
and harvest period of protein crystals for structure based drug design:
effects of a gel and a magnetic field on bovine adenosine deaminase crystals,
Acta Cryst. D59, 1333-1335 (2003).
43. H. Mori, Y. Urano, T. Kinoshita, S. Yoshimura, S. Takase, M. Hino,
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits
mammalian histone deacetylase III. Structure determination, J. Antibiotics56, 181-185 (2003).
42. K. Wada, T. Tada, Y. Nakamura, T. Kinoshita, M. Tamoi, S. Shigeoka,
K. Nishimura, Crystallization and preliminary X-ray diffraction studies
of catalase-peroxidase from Synechococcus PCC 7942, Acta Cryst. D58, 157-159 (2002).
41. T. Kinoshita, H. Miyake, T. Fujii, S. Takakura, T. Goto, The structure
of human recombinant aldose reductase complexed with the potent inhibitor
zenarestat, Acta Cryst. D58, 622-626 (2002).
40. K. Tsubaki, H. Tanaka, T. Kinoshita, K. Fuji, Synthesis of the proton-ionizable
lariat crown ether and chiral recognition of primary amines, Tetrahedron58, 1679-1684 (2002).
39. K. Tsubaki, H. Tanaka, T. Furuta, K. Tanaka, T. Kinoshita, K. Fuji,
Use of meso-ternaphthalene derivatives: linear recognition of the ,-diamines
by homoditopic receptors. Synthesis of the proton-ionizable lariat crown
ether and chiral recognition of primary amines, Tetrahedron58, 5611-5617 (2002).
38. A. Otaka, F. Katagiri, T. Kinoshita, Y. Odagaki, O. Shinya, H. Tamamura,
N. Hamanaka, N. Fujii, Regio- and stereoselective synthesis of (E)-alkene
trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-Sn2'
reactions, J. Org. Chem. 67, 6152-6161 (2002).
37. K. Tsubaki, K. Mukoyoshi, H. Morikawa, T. Kinoshita, K. Fuji, Enantiometric
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31. I. Nakanishi, T. Kinoshita, A. Sato, T. Tada, Structure of porcine
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30. S. Tabuchi, H. Ito, H. Sogabe, M. Kuno, T. Kinoshita, I. Katumi, N.
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29. S. Yoshimura, B. Sato, T. Kinoshita, S. Takase, H. Terano, A new antimitotic
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28. A. Otaka, E. Mitsuyama, T. Kinoshita, H. Tamamura, N. Fujii, Stereoselective
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26. T. Kawabata, J. Chen, H. Suzuki, Y. Nagae, T. Kinoshita, S.Chancharunee,
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25. T. Kinoshita, N. Nishio, A. Sato, M. Murata, Crystallization and preliminary
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24. I. Nakanishi, T. Kinoshita, T. Tada, T. Fujita, H. Hatanaka, A. Sato,
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23. A. Akahane, H. Katayama, T. Mitsunaga, T. Kato, T. Kinoshita, Y. Kita,
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22. S. Kuroda, A. Akahane, H. Itani, S. Nishimura, K. Durkin, T. Kinoshita,
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21. S. Kuroda, A. Akahane, H. Itani, S. Nishimura, K. Durkin, T. Kinoshita,
K. Sakane, Synthesis of the water-soluble adenosine A1 receptor antagonist
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20. K. Fuji, K. Tsubaki, K. Tanaka, N. Hayashi, T. Otsubo, T. Kinoshita,
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19. K. Tsubaki, Y. Murata, K. Komatsu, T. Kinoshita, K. Fuji, The supramolecular
structure of 1,4-bis(9-fluorenyl)-1,4-dihydro[60] fullerene with hexahomotrioxacalix[3]arene
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18. A. Tanaka, T. Terasawa, H. Hagihara, T. Kinoshita, Y. Sakuma, N. Ishibe,
M. Sawada, H. Takasugi, H. Tanaka, Synthesis, X-ray crystal structure,
and biological activity of FR186054, a novel, potent, orally active inhibitor
of acyl-CoA: cholesterol O-acyltransferase (ACAT) bearing a pyrazol ring,
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17. K. Fuji, T. Oka, T. Kawabata, T. Kinoshita, The first synthesis of
an optically active molecular bevel gear with only two cogs on each wheel,
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16. K. Tsubaki, T. Otsubo, K. Tanaka, K. Fuji, T. Kinoshita, Stepwise construction
of some hexahomooxacalix[3]arenes and their conformations in solid state,
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15. K. Tsubaki, K. Tanaka, T. Kinoshita, K. Fuji, Complexation of C60 with
hexahomooxacalix[3]arenes and supramolecular structures of complexes in
the solid state, Chem. Commun, 895-896 (1998).
14. K. Fuji, M. Sakurai, T. Kinoshita, T. Kawabata, Palladium-catalyzed
asymmetric reduction of allylic esters with a new chiral monodentate ligand,
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13. G. Kurisu, T. Kinoshita, A. Sugimoto, A. Nagara, Y. Kai, N. Kasai,
S. Harada, Structure of the zinc endoprotease from Streptomyces caespitosus,
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12. K. Fuji, M. Sakurai, T. Kinoshita, T. Tada, A. Kuroda, T. Kawabata,
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11. D. Barrett, H. Sasaki, H. Tsutsumi, T. Kinoshita, K. Sakane, Alkylation
of 1-[N-(hydroxymethyl)-N-methylamino]-4-quinolones. An improved preparation
of intermediates for novel potent tricyclic quinolone antibacterial agents,
Bull. Chem. Soc. Jpn. 69, 1371-1376 (1996).
10. D. Barrett, H. Sasaki, T. Kinoshita, A. Fujikawa, K. Sakane, A novel
synthesis of the pyrazolo[1,5-a]quinoline ring system. New N1-C2 bridged
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9. D. Barrett, H. Sasaki, T. Kinoshita, K. Sakane, A novel [3+2] annulation:
synthesis and X-ray crystallographic structure of a novel tetrahydropyrazolo[1,5-a]quinoline,
an intermediate towards new tricyclic quinolone antibacterials, Chem. Commun., 61-62 (1996).
8. M. Ohkubo, A. Kuno, K. Katsuta, Y. Ueda, K. Shirakawa, H. Nakanishi,
I. Nakanishi, T. Kinoshita, H. Takasugi, Studies on cerebral protective
agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-Methyl-D-aspartate
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7. M. Ohkubo, A. Kuno, K. Katsuta, Y. Ueda, K. Shirakawa, H. Nakanishi,
T. Kinoshita, H. Takasugi, Studies on Cerebral Protective Agents. X. Synthesis
and evaluation of anticonvulsant activities for novel 4,5,6,7-tetrahydrothieno[3,3-c]pyridines
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5. S. Harada, T. Kinoshita, N. Kasai, S., Tsunasawa, F. Sakiyama, Complete
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4. D. Barrett, H. Tsutsumi, T. Kinoshita, M. Murata, K. Sakane, Synthesis
of new 1,8-bridged tricyclic quinolones by a novel intramolecular arylation
of N-1 tethered malonamides, Tetrahedron51, 11125-11140 (1995).
3. K. Hattori, M. Nagano, T. Kato, I. Nakanishi, K. Imai, T. Kinoshita,
K. Sakane, Asymmetric synthesis of FR165914: a novel 3-adrenergic agonist
with a benzocycloheptane structure, Bioorg. Med. Chem. Lett. 5, 2821-282 (1995).
2. Y. Sato, T. Matsuo, H. Sogabe, H. Itoh, T. Tada, T. Kinoshita, K. Yoshida,
T. Takaya, Studies on a novel, potent and orally effective cheolecytokinin.
An antagonist, FK-480. Synthesis and structure-activity relationships of
FK-480 and related compounds, Chem. Pharm. Bull.42, 2071-2083 (1994).
1. S. Harada, K. Kitadokoro, T. Kinoshita, Y. Kai, N. Kasai, Crystallization
and main-chain structure of neutral protease from Streptomyces caespitosus,
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